Synthetic GPI array to study antitoxic malaria response

被引：93

作者：

Kamena, Faustin ^{[1
]}

Tamborrini, Marco ^{[2
]}

Liu, Xinyu ^{[1
]}

Kwon, Yong-Uk ^{[1
]}

Thompson, Fiona ^{[3
]}

Pluschke, Gerd ^{[2
]}

Seeberger, Peter H. ^{[1
]}

机构：

[1] ETH, Organ Chem Lab, Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland

[2] Swiss Trop Inst, CH-4002 Basel, Switzerland

[3] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Nuffield Dept Clin Med, Oxford OX3 7LJ, England

来源：

NATURE CHEMICAL BIOLOGY | 2008年 / 4卷 / 04期

关键词：

D O I：

10.1038/nchembio.75

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.

引用

页码：238 / 240

页数：3

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