The sodium phosphate cotransporter family SLC34

被引：231

作者：

Murer, H ^{[1
]}

Forster, I ^{[1
]}

Biber, J ^{[1
]}

机构：

[1] Univ Zurich Irchel, Inst Physiol, CH-8057 Zurich, Switzerland

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2004年 / 447卷 / 05期

关键词：

sodium-coupled phosphate transport; type ll Na/P-i-cotransporters; endocytosis;

D O I：

10.1007/s00424-003-1072-5

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

This review summarizes the characteristics of the solute carrier family SLC34 that is represented by the type ll Na/P-i-cotransporters NaPi-lla (SLC34A1), NaPi-llb (SLC34A2) and NaPi-llc (SLC34A3). Other Na/P-i-cotransporters are described within the SLC17 and SLC20 families. Type ll Na/P-i-cotransporters are expressed in several tissues and play a major role in the homeostasis of inorganic phosphate. In kidney and small intestine, type ll Na/P-i-cotransporters are located at the apical sites of epithelial cells and represent the rate limiting steps for transepithelial movement of phosphate. Physiological and pathophysiological regulation of renal and small intestinal epithelial transport of phosphate occurs through alterations in the abundance of type ll Na/P-i-cotransporters.

引用

页码：763 / 767

页数：5

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