Increased expression of HIV co-receptor CXCR4 on CD4+T-cells in patients with active visceral leishmaniasis

被引：5

作者：

Hailu, A

Pater, JM

Kager, PA

Van der Poll, T

机构：

[1] Univ Amsterdam, Acad Med Ctr, Lab Expt Internal Med, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Addis Ababa, Fac Med, Addis Ababa, Ethiopia

[3] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2004年 / 36卷 / 01期

关键词：

D O I：

10.1080/00365540310017546

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Enhanced expression of the human immunodeficiency virus (HIV) co-receptor CXCR4 renders T-lymphocytes more susceptible for infection with HIV. We demonstrate that patients with active visceral leishmaniasis have a higher proportion of circulating CD4+ T-cells expressing CXCR4 than healthy controls, suggesting that Leishmania may facilitate HIV infection of CD4+ lymphocytes.

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页码：56 / 58

页数：3

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