Opinion - Therapeutic vaccination for chronic diseases: a new class of drugs in sight

被引：91

作者：

Bachmann, MF ^{[1
]}

Dyer, MR ^{[1
]}

机构：

[1] Cytos Biotechnol AG, Schlieren, Switzerland

来源：

NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 01期

关键词：

D O I：

10.1038/nrd1284

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The induction of antibodies by prophylactic vaccination against infectious diseases has been the most effective medical intervention in human history. More recently, monoclonal antibodies specific for host proteins have proven to be highly effective for the treatment of acute and chronic diseases. However, the costs of protein therapies and their inconvenience for the patient are major obstacles for their widespread use. We suggest that the movement from the passive administration of monoclonal antibodies to active vaccination against self-molecules could be the next logical step in drug development, providing affordable medicines and broader patient acceptance and compliance.

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页码：81 / 88A

页数：8

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