Antioxidant and lipophilic constituents of Tinospora crispa

被引:137
作者
Cavin, A
Hostettmann, K
Dyatmyko, W
Potterat, O [1 ]
机构
[1] Univ Lausanne, Inst Pharmacognosie & Phytochim, BEP, CH-1015 Dorigny, Switzerland
[2] Univ Airlangga, Fak Pascasarjana, Surabaya, Indonesia
关键词
Tinospora crispa; Menispermaceae; antioxidants; free radical scavengers; secoisolariciresinol; N-feruloyltyramine; LC/MS;
D O I
10.1055/s-2006-957466
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
TLC autographic assays revealed in the CH2Cl2 extract of Tinospora crispo Miers (Menispermaceae) the presence of three compounds exhibiting antioxidant and radical scavenging properties towards beta-carotene and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. They were isolated and identified as N-cisferuloyltyramine (4), N-trans-feruloyltyramine (6) and secoisolariciresinol (5). When tested in dilution assays on the reduction of the DPPH radical, these 3 compounds proved to be more active than the synthetic antioxidant butylhydroxytoluene (BHT). Further investigation of the CH2Cl2 extract led to the isolation of vanillin, syringin, the alkaloid N-formylnornuciferin and the diterpene derivatives borapetosides B and C. In addition, a LC/UV/MS analysis enabled the on-line identification of borapetoside F and N-formylannonain.
引用
收藏
页码:393 / 396
页数:4
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