Inflammation and thrombosis

被引：355

作者：

Esmon, CT

机构：

[1] Oklahoma Med Res Fdn, Cardiovasc Biol Res Program, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA

[3] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK USA

[4] Howard Hughes Med Inst, Oklahoma City, OK USA

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2003年 / 1卷 / 07期

关键词：

inflammation; natural anticoagulants; thrombosis; vessel wall;

D O I：

10.1046/j.1538-7836.2003.00261.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic inflammation is a potent prothrombotic stimulus. Inflammatory mechanisms upregulate procoagulant factors. downregulate natural anticoagulants and inhibit fibrinolytic activity. In addition to modulating plasma coagulation mechanisms. inflammatory mediators appear to increase platelet reactivity. In vivo, however, natural anticoagulants not only prevent thrombosis, but they also dampen inflammatory activity. Some insights into the evolution and linkages between inflammatory mechanisms and the coagulation/anticoagulation mechanisms have become evident from recent structural studies. This review will summarize the interactions between inflammation and coagulation.

引用

收藏

页码：1343 / 1348

页数：6

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