Mitochondrial DNA population data of HVS-I and HVS-II sequences from a northeast German sample

被引：11

作者：

Tetzlaff, Sylvio

Brandstaeter, Anita

Wegener, Rudolf

Parson, Walther

Weirich, Volker

机构：

[1] Univ Rostock, Inst Legal Med, D-18055 Rostock, Germany

[2] Innsbruck Med Univ, Inst Legal Med, A-6020 Innsbruck, Austria

来源：

FORENSIC SCIENCE INTERNATIONAL | 2007年 / 172卷 / 2-3期

关键词：

mitochondrial DNA; hypervariable regions; haplotypes; population genetics; forensic science;

D O I：

10.1016/j.forsciint.2006.12.016

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Mitochondrial DNA sequences of the control region's two hypervariable regions HVS-I and HVS-II were determined for 213 unrelated west Eurasian individuals from northeast Germany (Mecklenburg). A total of 174 different mtDNA haplotypes were found, 25 of which were shared by more than 1 individual. The most frequent haplotypes were 2636-309.1C-315.1C, found in seven individuals, 2636-309.1C-309.2C-315.1 C, found in six individuals and 2636-315.1C, found in five individuals. These sequences are also the most common haplotypes in other published European data sets. The sequence polymorphisms consisting of 150 polymorphic nucleotide positions were compared with other European databases. The genetic diversity and random match probability were calculated. Our results corroborate certain features which are characteristic for west Eurasian mtDNA population samples. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：218 / 224

页数：7

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