CBF - A biophysical perspective

被引：20

作者：

Bushweller, JH ^{[1
]}

机构：

[1] Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2000年 / 11卷 / 05期

关键词：

core binding factor; CBF; Runx; AML1; leukemia; hematopoiesis; structure;

D O I：

10.1006/scdb.2000.0182

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Core binding factor (CBF) is a heterodimeric transcription factor consisting of a DNA-binding subunit (Runx also referred to as CBFA, AML 1, PEBP2 alpha) and a non-DNA-binding subunit (CBFB). Biophysical characterization of the two proteins and their interactions is providing a detailed understanding of this important transcription factor at the molecular level. Measurements of the relevant binding constants are helping to elucidate the mechanism of leukemogenesis associated with altered forms of these proteins. Determination of the 3D structures of CBFB and the DNA- and CBFB-binding domain of Runx, referred to as the Runt domain, are providing a structural basis for the functioning of the two proteins of CBF.

引用

页码：377 / 382

页数：6

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