共 122 条
Candidate targets for hepatitis C virus-specific antiviral therapy
被引:47
作者:

Bartenschlager, R
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h-index: 0
机构:
Univ Mainz, Inst Virol, D-55131 Mainz, Germany Univ Mainz, Inst Virol, D-55131 Mainz, Germany
机构:
[1] Univ Mainz, Inst Virol, D-55131 Mainz, Germany
关键词:
hepatitis C virus;
HCV chemotherapy;
HCV proteinase inhibitors;
HCV-specific antivirals;
NS3/4A proteinase complex of HCV;
HCV NS3 helicase;
HCV NS5B polymerase;
HCV replication;
D O I:
10.1159/000150570
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The hepatitis C virus (HCV) was identified as the major causative agent of posttransfusion and community-acquired non-A, non-B hepatitis throughout the world. It is an enveloped virus with a plus-strand RNA genome encoding a polyprotein of about 3,010 amino acids. This polyprotein is cleaved co- and posttranslationally into mature viral proteins by host cell signal peptidases and 2 viral enzymes designated the NS2-3 proteinase and the NS3/4A proteinase complex. It is assumed that virus replication takes place in a membrane-associated complex containing at least 2 viral enzymatic activities: the NS3 nucleoside triphosphatase (NTPase)/helicase and the NS5B RNA-dependent RNA polymerase (RdRp). Based on their important role for the viral life cycle and the wealth of information available for related cellular and viral proteins, the NS3/4A serine-type proteinase complex, the NS3 NTPase/helicase and the NS5B RdRp are the most attractive targets for development of HCV-specific antiviral therapies. This review will summarize our current knowledge about structure and function of these proteins and describe approaches pursued to identify effective antiviral compounds.
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页码:378 / 393
页数:16
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共 122 条
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