Organocatalytic synthesis of β-alkylaspartates via β-lactone ring opening

被引：13

作者：

Armstrong, Alan ^{[1
]}

Geldart, Stephen P. ^{[1
]}

Jenner, Chloe R. ^{[1
]}

Scutt, James N. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci & Technol, Dept Chem, London SW7 2AZ, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 21期

关键词：

D O I：

10.1021/jo701461t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Cinchona alkaloid-catalyzed reaction of ethyl glyoxylate with substituted ketenes, formed in situ, gives disubstituted beta-lactones in moderate yield and high enantiomeric excess. Subsequent azide ring opening, reduction, and ester hydrolysis allows access to chiral beta-alkyl aspartates.

引用

页码：8091 / 8094

页数：4

共 23 条

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