Preparation of 3-acetoacetylaminobenzo[b]furan derivatives with cysteinyl leukotriene receptor 2 antagonistic activity

被引：31

作者：

Tsuji, E

Ando, K

Kunitomo, J

Yamashita, M

Ohta, S

Kohno, S

Ohishi, Y

机构：

[1] Mukogawa Womens Univ, Sch Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

[2] Kyoto Pharmaceut Univ, Kyoto 6078412, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 18期

关键词：

D O I：

10.1039/b307468d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 3-acetoacetylaminobenzo[b] furan derivatives with a modified triene system at the 3-position were prepared through acylation of the 3-aminobenzo[b] furans with 5-methylisoxazole-4-carboxylic acid chloride followed by basic cleavage of the isoxazole ring and several of these compounds showed moderate cysteinyl leukotriene receptor 2 antagonistic activity.

引用

页码：3139 / 3141

页数：3

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