The array of Normalized Difference Vegetation Index (NDVI) products now being derived from satellite imagery open up new opportunities for the study of short and long-term variability in climate. Using a time series analysis procedure based on the Principal Components transform, and a sequence of monthly Advanced Very High Resolution Radiometer (AVHRR)-derived NDVI imagery from 1986 through 1990, we examine trends in variability of vegetation greenness for Africa for evidence of climatic trends. In addition to the anticipated seasonal trends, we identify signals of interannual variability. The most readily identified is one that periodically affects Southern Africa. It is shown that the temporal loadings for this component exhibit a very strong relationship with the El Nino/Southern Oscillation (ENSO) Index derived from atmospheric pressure patterns in the Pacific, Pacific sea surface temperature (SST) anomalies, and with anomalous Outgoing Longwave Radiation (OLR). However, we have also detected a second interannual variation, affecting most particularly East Africa and the Sahel, that does not exhibit a consistent ENSO relationship. The results show the teleconnection patterns between climatic conditions in the Pacific Ocean basin and vegetation conditions at specific regional locations over Africa. The comprehensive spatial character and high temporal resolution of these data offer exciting prospects for deriving a land surface index of ENSO and mapping the impacts of ENSO activity at continental scale. This study illustrates that vegetation reflectance data derived from polar orbiting satellites can serve as good proxy for the study of interannual climate variability.