Human homocysteine catabolism: Three major pathways and their relevance to development of arterial occlusive disease

被引:64
作者
Dudman, NPB [1 ]
Guo, XW [1 ]
Gordon, RB [1 ]
Dawson, PA [1 ]
Wilcken, DEL [1 ]
机构
[1] UNIV QUEENSLAND, PRINCESS ALEXANDRA HOSP, DEPT MED, BRISBANE, QLD 4102, AUSTRALIA
关键词
betaine; folate; homocysteine; human; occlusive vascular disease;
D O I
10.1093/jn/126.suppl_4.1295S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Two separate metabolic pathways that methylate homocysteine to methionine are known in humans, utilizing, respectively, 5-methyltetrahydrofolate and betaine as methyl donors, Deficiency of the folate-dependent methylation system is linked to hyperhomocysteinemia. Our data suggest that this deficiency leads to concurrent metabolic down-regulation of homocysteine transsulfuration that may contribute to hyperhomocysteinemia. By contrast, no instances have been reported of hyperhomocysteinemia resulting from deficiencies of betaine-dependent homocysteine methylation. Long-term betaine supplementation of 10 patients, who had pyridoxine-resistant homocystinuria and gross hyperhomocysteinemia due to deficiency of cystathionine beta-synthase activity, caused a substantial lowering of plasma homocysteine, which has now been maintained for periods of up to 13 years. Betaine had to be taken regularly because the effect soon disappeared when treatment was stopped. In conclusion, depressed activity of the transsulfuration pathway may contribute to hyperhomocysteinemia because of primary deficiencies of enzymes of either the transsulfuration or of the folate-dependent methylation pathways. Stimulation of betaine-dependent homocysteine remethylation causes a commensurate decrease in plasma homocysteine that can be maintained as long as betaine is taken.
引用
收藏
页码:S1295 / S1300
页数:6
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