Allelic expression and interleukin-2 polymorphisms in multiple sclerosis

被引：66

作者：

Matesanz, F

Fedetz, M

Collado-Romero, M

Fernández, O

Guerrero, M

Delgado, C

Alcina, A

机构：

[1] CSIC, Inst Parasitol & Biomed Lopez Neyra, Dept Immunol & Cellular Biol, Granada 18001, Spain

[2] Complejo Univ Carlos Haya, Serv Neurol, Malaga, Spain

[3] Hosp Clin San Cecilio, Serv Neurol, Granada, Spain

[4] SAS, Ctr Reg Transfus Sanguinea, Granada, Spain

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 119卷 / 01期

关键词：

interleukin-2; multiple sclerosis; autoimmunity; polymorphisms; allelic expression; detection;

D O I：

10.1016/S0165-5728(01)00354-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

We have investigated the association of two single nucleotide polymorphisms (SNPs) at positions -384 and 114 in the human interleukin-2 (hIL-2) with multiple sclerosis (MS). For two of the -384 genotypes (G/T, T/T), we observed an association with the susceptibility to secondary progressive (SP) course of MS ( P=0.005 and P=0.013, respectively). Expression level differences of the IL-2 alleles (between one- and three-fold) were not attributable to the -384 promoter polymorphism, These data indicate for the first time the relevance of the il-2 gene locus in human MS and its possible involvement in other autoimmune diseases. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：101 / 105

页数：5

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