Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma

被引:131
作者
Rajkumar, SV [1 ]
Fonseca, R [1 ]
Witzig, TE [1 ]
Gertz, MA [1 ]
Greipp, PR [1 ]
机构
[1] Mayo Clin & Mayo Fdn, Div Hematol, Rochester, MN 55905 USA
关键词
multiple myeloma; angiogenesis; microvessel density; complete response; stem cell transplantation;
D O I
10.1038/sj.leu.2401336
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Although most of the initial studies in angiogenesis were done on solid tumors, there is now data suggesting the importance of angiogenesis in hematologic malignancies. We estimated bone marrow microvessel density before autologous stem cell transplantation and at the time of response in 13 patients with myeloma (seven complete and six partial responders) using an immunohistochemical stain for factor VIII-related antigen (von Willebrand factor). Baseline microvessel density was significantly different between bone marrow samples from patients with myeloma and morphologically normal, staging marrows from patients with limited stage Hodgkin's disease, mean (+/- s.d.) 294 (+/-115)/mm(2) vs 93 (+/-26)/mm(2), respectively, P = 0.001. After transplantation, microvessel density continued to be high in myeloma samples compared to samples from control patients with limited stage Hodgkin's disease, mean (+/- s.d.) 230 (+/-68)/mm(2), P = 0.003. There was no difference in microvessel density at the time of complete or partial response compared to values prior to transplantation. This report confirms that increased angiogenesis is found in myeloma bone marrow prior to transplantation, and suggests that increased angiogenesis persists even after complete response.
引用
收藏
页码:469 / 472
页数:4
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