A column-based 'flush and flow' system for the asymmetric α-chlorination of acid halides

被引：29

作者：

Bernstein, D ^{[1
]}

France, S ^{[1
]}

Wolfer, J ^{[1
]}

Lectka, T ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 21期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tetasy.2005.09.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We describe a column based flow system in which a cinchona alkaloid based reagent/catalyst solid-phase promotes the asymmetric a-chlorination of acid chlorides to afford highly optically active alpha-chloroesters in high enantiomeric excess and in good yields. (c) 2005 Published by Elsevier Ltd.

引用

页码：3481 / 3483

页数：3

共 19 条

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