A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging

被引：19

作者：

Giacconi, Robertina ^{[1
]}

Muti, Elisa ^{[1
]}

Malavolta, Marco ^{[1
]}

Cardelli, Maurizio ^{[2
]}

Pierpaoli, Sara ^{[1
]}

Cipriano, Catia ^{[1
]}

Costarelli, Laura ^{[1
]}

Tesei, Silvia ^{[1
]}

Saba, Vittorio ^{[3
]}

Mocchegiani, Eugenio ^{[1
]}

机构：

[1] INRCA Ancona, Dept Res, Ctr Immunol, Sect Nutr Immun & Ageing, I-60121 Ancona, Italy

[2] INRCA Ancona, Dept Res, Ctr Genet & Mol Biol, I-60121 Ancona, Italy

[3] INRCA Hosp, Ancona, Italy

来源：

REJUVENATION RESEARCH | 2008年 / 11卷 / 02期

关键词：

D O I：

10.1089/rej.2008.0671

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Zinc deficiency represents a risk factor for carotid stenosis (CS) development. In mammals, members of the ZIP family regulate zinc uptake, and hZip2 is a human zinc importer upregulated by zinc depletion. The purpose of this study was to investigate the association of a novel Zip2 Gln/Arg/Leu codon 2 polymorphism with CS, analyzing 250 CS patients and 259 elderly controls. CS patients showed an increased GG genotype frequency (60% vs. 47.5%), and a reduced TT frequency (6% vs. 10%) (p < 0.05 by chi(2) test). In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease.

引用

页码：297 / 300

页数：4

共 19 条

[1] The galvanization of biology: A growing appreciation for the roles of zinc [J].

Berg, JM ;

Shi, YG .

SCIENCE, 1996, 271 (5252) :1081-1085

[2]

Cao J, 2001, J LEUKOCYTE BIOL, V70, P559

[3] A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells [J].

Cousins, RJ ;

Blanchard, RK ;

Popp, MP ;

Liu, L ;

Cao, J ;

Moore, JB ;

Green, CL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (12) :6952-6957

[4] Structure, function, and regulation of a subfamily of mouse zinc transporter genes [J].

Dufner-Beattie, J ;

Langmade, SJ ;

Wang, FD ;

Eide, D ;

Andrews, GK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (50) :50142-50150

[5]

FAURE P, 1995, EUR J CLIN NUTR, V49, P282

[6] Functional expression of the human hZIP2 zinc transporter [J].

Gaither, LA ;

Eide, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (08) :5560-5564

[7] The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people [J].

Giacconi, Robertina ;

Muti, Elisa ;

Malavolta, Marco ;

Cipriano, Catia ;

Costarelli, Laura ;

Bernardini, Gianni ;

Gasparini, Nazzarena ;

Mariani, Erminia ;

Saba, Vittorio ;

Boccoli, Gianfranco ;

Mocchegiani, Eugenio .

MOLECULAR MEDICINE, 2007, 13 (7-8) :388-395

[8] Involvement of-308 TNF-α and 1267 Hsp70-2 polymorphisms and zinc status in the susceptibility of coronary artery disease (CAD) in old patients [J].

Giacconi, Robertina ;

Cipriano, Catia ;

Muti, Elisa ;

Costarelli, Laura ;

Malavolta, Marco ;

Caruso, Calogero ;

Lio, Domenico ;

Mocchegiani, Eugenio .

BIOGERONTOLOGY, 2006, 7 (5-6) :347-356

[9] Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency [J].

Grotz, N ;

Fox, T ;

Connolly, E ;

Park, W ;

Guerinot, ML ;

Eide, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :7220-7224

[10] Human zinc deficiency [J].

Hambidge, M .

JOURNAL OF NUTRITION, 2000, 130 (05) :1344S-1349S

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