Rational recognition of nucleic acid sequences

被引：29

作者：

Iida, H ^{[1
]}

Jia, GF ^{[1
]}

Lown, JW ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0958-1669(99)80006-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent progress in synthetic and computational chemistry has made it possible to develop certain novel drug candidates. Drug candidates for genetic diseases, such as cancer, may also be designed on the basis of structural information obtained using X-ray analysis and NMR, as well as evidence from biological techniques applied to natural products - DNA (or RNA) complexes and conjugates. The resulting designed drug candidates exhibit promising performance based on the recognition on nucleic acid sequences.

引用

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页码：29 / 33

页数：5

相关论文

共 38 条

[1]

Altmann KH, 1998, ADV DNA SEQ, P227

[2] SYNTHESIS, DNA-BINDING PROPERTIES, AND ANTITUMOR-ACTIVITY OF NOVEL DISTAMYCIN DERIVATIVES [J].

ARCAMONE, FM ;

ANIMATI, F ;

BARBIERI, B ;

CONFIGLIACCHI, E ;

DALESSIO, R ;

GERONI, C ;

GIULIANI, FC ;

LAZZARI, E ;

MENOZZI, M ;

MONGELLI, N ;

PENCO, S ;

VERINI, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (04) :774-778

[3]

Bailly C, 1998, ADV DNA SEQ, P97

[4] Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids [J].

Baird, EE ;

Dervan, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (26) :6141-6146

[5] TEMPLATE SWITCHING BETWEEN PNA AND RNA OLIGONUCLEOTIDES [J].

BOHLER, C ;

NIELSEN, PE ;

ORGEL, LE .

NATURE, 1995, 376 (6541) :578-581

[6] CRYSTAL-STRUCTURE OF A BERENIL DODECANUCLEOTIDE COMPLEX - THE ROLE OF WATER IN SEQUENCE-SPECIFIC LIGAND-BINDING [J].

BROWN, DG ;

SANDERSON, MR ;

SKELLY, JV ;

JENKINS, TC ;

BROWN, T ;

GARMAN, E ;

STUART, DI ;

NEIDLE, S .

EMBO JOURNAL, 1990, 9 (04) :1329-1334

[7] Drug-DNA interactions [J].

Chaires, JB .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1998, 8 (03) :314-320

[8] Backbone and benzoyl mustard carrying moiety modifies DNA interactions of distamycin analogues [J].

Ciucci, A ;

Manzini, S ;

Lombardi, P ;

Arcamone, F .

NUCLEIC ACIDS RESEARCH, 1996, 24 (02) :311-315

[9] Designer DNA-binding drugs: The crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)(2) [J].

Clark, GR ;

Squire, CJ ;

Gray, EJ ;

Leupin, W ;

Neidle, S .

NUCLEIC ACIDS RESEARCH, 1996, 24 (24) :4882-4889

[10] A BIFURCATED HYDROGEN-BONDED CONFORMATION IN THE D(A.T) BASE-PAIRS OF THE DNA DODECAMER D(CGCAAATTTGCG) AND ITS COMPLEX WITH DISTAMYCIN [J].

COLL, M ;

FREDERICK, CA ;

WANG, AHJ ;

RICH, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) :8385-8389

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