Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury

被引：115

作者：

Fu, Qiang ^{[1
,2
]}

Huang, Xiao ^{[1
,3
]}

Shu, Bin ^{[4
]}

Xue, Mei ^{[1
]}

Zhang, Pinghu ^{[3
]}

Wang, Tao ^{[3
]}

Liu, Li ^{[5
]}

Jiang, Zhenzhou ^{[1
]}

Zhang, Luyong ^{[1
]}

机构：

[1] China Pharmaceut Univ, Jiangsu Ctr Drug Screening, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing 211198, Peoples R China

[3] China Pharmaceut Univ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China

[4] Nanjing Univ Technol, Jiangsu Ctr Safety Evaluat Drugs, Nanjing 210009, Peoples R China

[5] Yangzhou Univ, Dept Pharmacol, Sch Med, Yangzhou 225001, Peoples R China

来源：

FITOTERAPIA | 2011年 / 82卷 / 08期

关键词：

Triptolide; Mitochondria; Liver injury; Microvesicular steatosis; Hyperlactacidemia; BETA-OXIDATION; TRIPTERYGIUM-WILFORDII; FATTY-ACIDS; HEPATOTOXICITY; DYSFUNCTION; DRUGS; STEATOHEPATITIS;

D O I：

10.1016/j.fitote.2011.08.019

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Triptolide, a diterpenoid epoxide, is one of the major active ingredients of Tripterygium wilfordii Hook F, a woody vine plant called lei gong teng in China, which is used in traditional Chinese Medicine (TCM) for treating many diseases. In this paper, we investigate the relation between inhibition of mitochondrial respiratory chain and liver injury induced by triptolide. Results indicate that the secondary IS-oxidation impairment caused by inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury, which featured by microvesicular steatosis, hyperlactacidemia and enhanced oxidant stress, although other mechanisms of triptolide-induced liver injury may also exist. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1241 / 1248

页数：8

共 20 条

[1]

Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes [J].