Peripheral metabolism of thyroid hormone and glucose homeostasis

被引：79

作者：

Chidakel, A

Mentuccia, D

Celi, FS

机构：

[1] NIDDKD, Clin Endocrinol Brnach, NIH, Bethesda, MD 20892 USA

[2] Univ Roma Tor Vergata, Div Endocrinol, Dept Med, Rome, Italy

来源：

THYROID | 2005年 / 15卷 / 08期

关键词：

D O I：

10.1089/thy.2005.15.899

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyroid hormone action has long been recognized as an important determinant of glucose homeostasis. Recent advances in the knowledge of the physiology of the deiodinases indicate that through tissue-specific regulation of thyroid hormone metabolism, leading to local specificity of thyroid hormone action and target gene transcription patterns, they may have an important function in the modulation of carbohydrate metabolism. This review briefly addresses the role of thyroid hormone action on glucose homeostasis with a specific focus on the significance of the peripheral metabolism of thyroid hormone in the regulation of glucose homeostasis and insulin sensitivity.

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收藏

页码：899 / 903

页数：5

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