Correlates of excessive daytime sleepiness in Parkinson's disease

被引：23

作者：

Wegelin, J

McNamara, P

Durso, R

Brown, A

McLaren, D

机构：

[1] Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Div Biostat, Sacramento, CA 95817 USA

[2] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA

[3] VA Boston Healthcare Syst, Boston, MA 02130 USA

来源：

PARKINSONISM & RELATED DISORDERS | 2005年 / 11卷 / 07期

关键词：

excessive daytime sleepiness; Parkinson's disease; neuropsychology; mood; executive functions; dopamine agonists;

D O I：

10.1016/j.parkreldis.2005.05.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Measures of excessive daytime sleepiness, neuropsychologic function, and mood were assessed in twenty-two persons with mid-stage Parkinson's disease (PD) and sixteen age-matched healthy controls. Levodopa dose equivalents (LDE) were computed for the patients. While Epworth sleepiness score (ESS), Mini Mental State Exam, logical memory, Stroop, and the mood scales, reliably distinguished patients from controls, only the mood scales (especially anxiety) were reliably associated with ESS. LDE was not significantly associated with ESS. Excessive daytime sleepiness in patients with mid-stage PD may be more strongly related to anxiety than to other neuropsychologic dysfunction or dopaminergic dosing levels. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：441 / 448

页数：8

共 56 条

[1]

Aggleton J.P., 2000, AMYGDALA FUNCTIONAL, V2nd

[2]

Agid Y., 1987, MOVEMENT DISORD, V2, P166

[3] Decreased striatal dopaminergic innervation in REM sleep behavior disorder [J].