Regulation of in situ to invasive breast carcinoma transition

被引：395

作者：

Hu, Min ^{[3
,10
]}

Yao, Jun ^{[3
,10
]}

Carroll, Danielle K. ^{[3
]}

Weremowicz, Stanislawa ^{[2
,3
]}

Chen, Haiyan ^{[1
,4
]}

Carrasco, Daniel ^{[10
]}

Richardson, Andrea ^{[2
,3
]}

Violette, Shelia ^{[5
]}

Nikolskaya, Tatiana ^{[6
]}

Nikolsky, Yuri ^{[6
]}

Bauerlein, Erica L. ^{[3
,10
]}

Hahn, William C. ^{[3
,10
]}

Gelman, Rebecca S. ^{[1
,4
]}

Allred, Craig ^{[7
]}

Bissell, Mina J. ^{[9
]}

Schnitt, Stuart ^{[3
,8
]}

Polyak, Kornelia ^{[3
,10
]}

机构：

[1] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[5] Biogen Idec Inc, Cambridge, MA 02142 USA

[6] GeneGo Inc, St Joseph, MI 49085 USA

[7] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA

[8] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA

[9] Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA

[10] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

来源：

CANCER CELL | 2008年 / 13卷 / 05期

关键词：

D O I：

10.1016/j.ccr.2008.03.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors. Progression to invasion was promoted by fibroblasts and inhibited by normal myoepithelial cells. Molecular profiles of isolated luminal epithelial and myoepithelial cells identified an intricate interaction network involving TGF beta, Hedgehog, cell adhesion, and p63 required for myoepithelial cell differentiation, the elimination of which resulted in loss of myoepithelial cells and progression to invasion.

引用

页码：394 / 406

页数：13

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