A novel variable number of tandem repeat polymorphism of the renin gene and essential hypertension

被引：11

作者：

Hasimu, B

Nakayama, T

Mizutani, Y

Izumi, Y

Asai, S

Soma, M

Kokubun, S

Ozawa, Y

机构：

[1] Adv Med Res Ctr, Div Receptor Biol, Itabashi Ku, Tokyo 1738610, Japan

[2] Adv Med Res Ctr, Div Genet & Genom Med, Itabashi Ku, Tokyo 1738610, Japan

[3] Nihon Univ, Dept Internal Med 2, Tokyo, Japan

来源：

HYPERTENSION RESEARCH | 2003年 / 26卷 / 06期

关键词：

renin gene; variable number of tandem repeat; essential hypertension; polymorphism; association study;

D O I：

10.1291/hypres.26.473

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The aims of the present study were to find new genetic markers of essential hypertension (EH) and to investigate relationships between EH and polymorphisms of the renin gene. Using single strand conformation polymorphism, we discovered a new variable number of tandem repeat (VNTR) polymorphism in intron 7 that is 18 bp upstream from the boundary with exon 8. Nucleotide sequencing revealed that this VNTR polymorphism is a tandem repeat of the 4-nucleotide sequence TCTG. There were 6 alleles of this VNTR polymorphism, ranging from 7 repeats to 12 repeats. We analyzed the association between EH and this VNTR polymorphism. There was no significant difference in the overall distribution of this VNTR polymorphism between the EH and normotensive subjects. In summary, we discovered a novel VNTR polymorphism in the renin gene, and this polymorphism was not associated with EH.

引用

页码：473 / 477

页数：5

共 26 条

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