Viral determinants of rotavirus pathogenicity in pigs: Evidence that the fourth gene of a porcine rotavirus confers diarrhea in the homologous host

被引：20

作者：

Bridger, JC

Tauscher, GI

Desselberger, U

机构：

[1] Univ London Royal Vet Coll, Dept Pathol & Infect Dis, London NW1 0TU, England

[2] Univ Cambridge, Addenbrookes Hosp, Clin Microbiol & Publ Hlth Lab, Cambridge CB2 2QW, England

[3] Univ Cambridge, Addenbrookes Hosp, Dept Pathol, Div Virol, Cambridge CB2 2QW, England

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.72.8.6929-6931.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A porcine rotavirus (prv) monoreassortant, S-F4, which carries RNA segment 4 of the pig-pathogenic variant pry 4F in the genetic bachground of the pig-apathogenic variant prv 4S (G. I; Tanscher and U. Desselberger, J. Virol. 71:853-857, 1997), was found to be pathogenic in gnotobiotic piglets. This indicates that RNA segment 4 of the pig-pathogenic variant prv 4F is a major determinant of pathogenicity in its homologous host.

引用

页码：6929 / 6931

页数：3

共 23 条

[1] Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein [J].