Molecular basis of the CRAC channel

被引：135

作者：

Cahalan, Michael D. ^{[1
]}

Zhang, Shenyuan L.

Yeromin, Andriy V.

Ohlsen, Kari

Roos, Jack

Stauderman, Kenneth A.

机构：

[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Ctr Immunol, Irvine, CA 92697 USA

[3] TorreyPines Therapeut Inc, La Jolla, CA 92037 USA

来源：

CELL CALCIUM | 2007年 / 42卷 / 02期

关键词：

CRAC channel; T lymphocyte; store-operated calcium; stim; orai;

D O I：

10.1016/j.ceca.2007.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ca2+ release-activated Ca 2, (CRAC) channels, located in the plasma membrane, are opened upon release of Ca 2, from intracellular stores, permitting Ca2+ entry and sustained [Ca2+], signaling that replenishes the store in numerous cell types. This mechanism is particularly important in T lymphocytes of the immune system, providing the missing link in the signal transduction cascade that is initiated by T cell receptor engagement and leads to altered expression of genes that results ultimately in the production of cytokines and cell proliferation. In the past three years, RNA interference screens together with over-expression and site-directed mutagenesis have identified the triggering molecule (Stim) that links store depletion to CRAC channel-mediated Ca2+ influx and the pore subunit (Orai) of the CRAC channel that allows highly selective entry of Ca 2, ions into cells. (C) 2007 Published by Elsevier Ltd.

引用

页码：133 / 144

页数：12

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