From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs

被引：149

作者：

Bandell, Michael

Macpherson, Lindsey J.

Patapoutian, Ardem ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2007年 / 17卷 / 04期

关键词：

D O I：

10.1016/j.conb.2007.07.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Six highly temperature-sensitive ion channels of the transient receptor potential (TRP) family have been implicated to mediate temperature sensation. These channels, expressed in sensory neurons innervating the skin or the skin itself, are active at specific temperatures ranging from noxious cold to burning heat. In addition to temperature sensation thermoTRPs are the receptors of a growing number of environmental chemicals (chemesthesis). Recent studies have provided some striking new insights into the molecular mechanism of thermal and chemical activation of these biological thermometers.

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收藏

页码：490 / 497

页数：8

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