Predictive Utility of Type and Duration of Symptoms at Initial Presentation in Patients with Mild Cognitive Impairment

被引：24

作者：

Devier, Deidre J. ^{[1
]}

Villemarette-Pittman, Nicole ^{[1
]}

Brown, Patrick ^{[2
,3
,4
]}

Pelton, Gregory ^{[2
,3
,4
]}

Stern, Yaakov ^{[2
,3
,4
]}

Sano, Mary ^{[5
,6
,7
]}

Devanand, D. P. ^{[2
,3
,4
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Neurol, New Orleans, LA 70112 USA

[2] Columbia Univ Coll Phys & Surg, Div Geriatr Psychiat, New York, NY 10032 USA

[3] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[4] Taub Inst Res Alzheimers Dis & Aging Brain, Sergievsky Ctr, Dept Neurol, New York, NY USA

[5] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA

[6] Mt Sinai Sch Med, Alzheimers Dis Res Ctr, New York, NY USA

[7] James J Peters VA Med Ctr, Dept Neurol, Bronx, NY USA

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2010年 / 30卷 / 03期

关键词：

Age at onset; Alzheimer's disease; Behavioral symptoms; Mild cognitive impairment; Neuropsychological assessment; ALZHEIMERS-DISEASE; MEMORY COMPLAINTS; OBJECTIVE MEMORY; DEMENTIA; ONSET; CONVERSION; DIAGNOSIS; AGE; COMMUNITY; ANOSOGNOSIA;

D O I：

10.1159/000320137

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Background/Aims: To assess (1) the duration and symptoms present in participants with mild cognitive impairment (MCI) and (2) the impact of these variables on predicting conversion to Alzheimer's disease (AD). Methods: Participants with MCI (n = 148) were assessed and followed systematically. Results: Decline in memory was reported as the first symptom in 118 of the cases. Converters had more symptoms (e. g. language decline, depression), and the combination of decline in memory and in performance of high-order social/cognitive activities as well as disorientation more often than non-converters (p = 0.036). In an age-stratified Cox model, predictors of conversion to AD were shorter time since onset of memory decline and lower baseline MMSE score. Conclusions: Recent onset of memory decline with older age, decreased MMSE score, change in performance and disorientation indicate a greater likelihood of short-term conversion to AD. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：238 / 244

页数：7

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