Cyclolignans from Scyphocephalium ochocoa via high-throughput natural product chemistry methods

被引：22

作者：

Hu, JF ^{[1
]}

Garo, E ^{[1
]}

Yoo, HD ^{[1
]}

Cremin, PA ^{[1
]}

Goering, MG ^{[1
]}

O'Neil-Johnson, M ^{[1
]}

Eldridge, GR ^{[1
]}

机构：

[1] Sequoia Sci Inc, Lead Discovery & Rapid Struct Elucidat Grp, San Diego, CA 92121 USA

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 09期

关键词：

Scyphocephalium ochocoa; myristicaceae; high-throughput natural product chemistry; CapNMR (TM) probe; miniaturization; structure elucidation; cyclolignans; ocholignans; antibacterial;

D O I：

10.1016/j.phytochem.2005.03.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two 2,7 '-cyclolignans, ocholignans A and B, were obtained as mass-limited samples from Scyphocephalium ochocoa via high-throughput natural products chemistry methods. The rapid structure elucidation of each compound was primarily facilitated by NMR data acquisition using a capillary-scale NMR probe, CapNMR (TM) probe. Ocholignan A was found to possess significant in vitro antibacterial activity against Gram-positive bacteria methicillin-resistant Staphylococcus aureus ATCC 33591 and S. aureus 78-13607A with a MIC of 16 mu g/mL, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1077 / 1082

页数：6

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