Enkelytin and opioid peptide association in invertebrates and vertebrates: immune activation and pain

被引：85

作者：

Stefano, GB

Salzet, B

Fricchione, GL

机构：

[1] SUNY Coll Old Westbury, Neurosci Res Inst, Old Westbury, NY 11568 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Psychiat, Boston, MA 02115 USA

[3] Beth Israel Deaconess Med Ctr, Mind Body Med Inst, Boston, MA 02115 USA

[4] Univ Sci & Tech Lille Flandres Artois, Grp Neuroendocrinol Hirudinees, Lab Phylogenie Mol Annelides, Ctr Biol Cellulaire,DRED,EA 1027, F-59655 Villeneuve Dascq, France

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(98)01268-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Invertebrates contain an opioid precursor, proenkephalin. Enkelytin, an antibacterial peptide, is found in invertebrate proenkephalin, exhibiting 98% sequence identity with mammalian enkephalin. Here, George Stefano and colleagues surmise that the function of enkelytin is to attack bacteria and allow time for the immunocyte-stimulating capabilities of the opioid peptides to emerge. Furthermore, they propose that pain itself is a component of this response.

引用

页码：265 / 268

页数：4

共 28 条

[1] [Anonymous], FUTURE INTELLIGENCE
[2] Immunologic dissonance: A continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS)
Bone, RC
[J]. ANNALS OF INTERNAL MEDICINE, 1996, 125 (08) : 680 - 687
[3] Chapman CR, 1987, PSYCHOL PAIN, P169
[4] IMMUNOSUPPRESSION IN THE DEFINITIVE AND INTERMEDIATE HOSTS OF THE HUMAN PARASITE SCHISTOSOMA-MANSONI BY RELEASE OF IMMUNOACTIVE NEUROPEPTIDES
DUVAUXMIRET, O
STEFANO, GB
SMITH, EM
DISSOUS, C
CAPRON, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (02) : 778 - 781
[5] EWANDINGER NM, 1996, BRAIN RES, V737, P1
[6] Surgical anticipatory stress manifests itself in immunocyte desensitization: Evidence for autoimmunoregulatory involvement
Fricchione, G
Bilfinger, TV
Jandorf, L
Smith, EM
Stefano, GB
[J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 1996, 53 : S65 - S73
[7] GABRIEL M, 1991, EXP BRAIN RES, V86, P585
[8] The C-terminal bisphosphorylated proenkephalin-A-(209-237)-peptide from adrenal medullary chromaffin granules possesses antibacterial activity
Goumon, Y
Strub, JM
Moniatte, M
Nullans, G
Poteur, L
Hubert, P
VanDorsselaer, A
Aunis, D
MetzBoutigue, MH
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 235 (03): : 516 - 525
[9] ISOLATION AND IDENTIFICATION OF ENKEPHALINS IN PEDAL GANGLIA OF MYTILUS-EDULIS (MOLLUSCA)
LEUNG, MK
STEFANO, GB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (03): : 955 - 958
[10] ISOLATION, SEQUENCE-ANALYSIS, AND PHYSIOLOGICAL-PROPERTIES OF ENKEPHALINS IN THE NERVOUS-TISSUE OF THE SHORE CRAB CARCINUS-MAENAS L
LUSCHEN, W
BUCK, F
WILLIG, A
JAROS, PP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) : 8671 - 8675

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