A neuroglobin-overexpressing transgenic mouse

被引：27

作者：

Khan, Adil A. ^{[1
]}

Sun, Yunjuan ^{[1
]}

Jin, Kunlin ^{[1
]}

Mao, Xiao Ou ^{[1
]}

Chen, Sylvia ^{[1
]}

Ellerby, Lisa M. ^{[1
]}

Greenberg, David A. ^{[1
]}

机构：

[1] Buch Inst Age Res, Novato, CA 94945 USA

来源：

GENE | 2007年 / 398卷 / 1-2期

关键词：

oxygen; globin; hypoxia; ischemia; brain; neuron;

D O I：

10.1016/j.gene.2007.02.044

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic, mouse in which Ngb is overexpressed under the control of the chicken beta-actin promoter. This mouse should prove helpful for studying Ngb-mediated effects in vitro and in vivo. (c) 2007 Elsevier B.V. All rights reserved.

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收藏

页码：172 / 176

页数：5

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