DNA double-strand break repair and the evolution of intron density

被引：40

作者：

Farlow, Ashley ^{[1
]}

Meduri, Eshwar ^{[1
]}

Schloetterer, Christian ^{[1
]}

机构：

[1] Vetmeduni Vienna, Inst Populat Genet, Vienna, Austria

来源：

TRENDS IN GENETICS | 2011年 / 27卷 / 01期

基金：

奥地利科学基金会;

关键词：

HOMOLOGOUS RECOMBINATION; GENES; GAIN; PATHWAYS; EXPRESSION; DROSOPHILA; STRESS; GENOME; YEAST; RATES;

D O I：

10.1016/j.tig.2010.10.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The density of introns is both an important feature of genome architecture and a highly variable trait across eukaryotes. This heterogeneity has posed an evolutionary puzzle for the last 30 years. Recent evidence is consistent with novel introns being the outcome of the error-prone repair of DNA double-stranded breaks (DSBs) via non-homologous end joining (NHEJ). Here we suggest that deletion of pre-existing introns could occur via the same pathway. We propose a novel framework in which species-specific differences in the activity of NHEJ and homologous recombination (HR) during the repair of DSBs underlie changes in intron density.

引用

页码：1 / 6

页数：6

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