Boromycin, an anti-HIV antibiotic

被引：58

作者：

Kohno, J

Kawahata, T

Otake, T

Morimoto, M

Mori, H

Ueba, N

Nishio, M

Kinumaki, A

Komatsubara, S

Kawashima, K

机构：

[1] OSAKA PREFECTURAL INST PUBL HLTH, DEPT PATHOL, HIGASHINARI KU, OSAKA 537, JAPAN

[2] TANABE SEIYAKU CO LTD, LEAD OPTIMIZAT RES LAB, TODA, SAITAMA 335, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 06期

关键词：

boromycin; anti-HIV;

D O I：

10.1271/bbb.60.1036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in in vitro laboratory experiments. The mechanism for the anti-HIV activity of boromycin is suggested to involve blocking the later stage of HIV infection, and probably the maturity step for replication of the HIV molecule.

引用

页码：1036 / 1037

页数：2

共 7 条

[1]

Hahn F. E., 1975, ANTIBIOTICS, VIII, P585

[2] STOFFWECHSELPRODUKTE VON MIKROORGANISMEN [J].

HUTTER, R ;

KELLERSC.W ;

KNUSEL, F ;

PRELOG, V ;

RODGERS, GC ;

SUTER, P ;

VOGEL, G ;

VOSER, W ;

ZAHNER, H .

HELVETICA CHIMICA ACTA, 1967, 50 (06) :1533-&

[3]

Miller MB, 1975, U.S. Patent, Patent No. 3864479

[4] POTENT INHIBITORY EFFECT OF A SERIES OF MODIFIED CYCLODEXTRIN SULFATES (MCDS) ON THE REPLICATION OF HIV-1 INVITRO [J].

MORIYA, T ;

KURITA, H ;

MATSUMOTO, K ;

OTAKE, T ;

MORI, H ;

MORIMOTO, M ;

UEBA, N ;

KUNITA, N .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (07) :2301-2304

[5]

NAKANO T, 1994, J JPN ASS INFECT DIS, V68, P923

[6]

OTAKE T, 1990, JPN J A INFECT DIS, V64, P1287

[7] NMR ANALYSIS OF BOROMYCIN SODIUM COMPLEX AND SODIUM DESVALINOBOROMYCINATE [J].

SOMERS, TC ;

WHITE, JD ;

LEE, JJ ;

KELLER, PJ ;

CHANG, C ;

FLOSS, HG .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (04) :464-471

← 1 →