PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A

被引:307
作者
Moskowitz, SM
Ernst, RK
Miller, SI
机构
[1] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA
[2] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA
[3] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
关键词
D O I
10.1128/JB.186.2.575-579.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Spontaneous polymyxin-resistant mutants of Pseudomonas aeruginosa were isolated. The mutations responsible for this phenotype were mapped to a two-component signal transduction system similar to PmrAB of Salmonella enterica serovar Typhimurium. Lipid A of these mutants contained aminoarabinose, an inducible modification that is associated with polymyxin resistance. Thus, P. aeruginosa possesses a mechanism that induces resistance to cationic antimicrobial peptides in response to environmental conditions.
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页码:575 / 579
页数:5
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