Cerebral phosphate metabolism in first-degree relatives of patients with schizophrenia

被引：32

作者：

Klemm, S ^{[1
]}

Rzanny, R ^{[1
]}

Riehemann, S ^{[1
]}

Volz, HP ^{[1
]}

Schmidt, B ^{[1
]}

Gerhard, UJ ^{[1
]}

Filz, C ^{[1
]}

Schönberg, A ^{[1
]}

Mentzel, HJ ^{[1
]}

Kaiser, WA ^{[1
]}

Blanz, B ^{[1
]}

机构：

[1] Univ Jena, Dept Child & Adolescent Psychiat, Dept Psychiat, Inst Diagnost & Intervent Radiol, D-07740 Jena, Germany

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2001年 / 158卷 / 06期

关键词：

D O I：

10.1176/appi.ajp.158.987.958

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Most phosphorus-31 magnetic resonance spectroscopy (P-31-MRS) studies have described measures of lower membrane anabolism or greater catabolism in the frontal lobes of patients with schizophrenia. The purpose of the present study was to evaluate whether these findings can also be detected in young subjects at genetic risk for schizophrenia. Method: Fourteen children and siblings of patients with schizophrenia (mean age=16.7 years) and 14 comparison subjects (mean age=16.9 years) were included in a P-31-MRS study of the frontal robe. Results: The high-risk subjects had significantly lower mean ratios of phosphomonoesters to phosphodiesters (0.25 versus 0.31) and higher mean phosphodiester values (37.59% versus 34.87%) than comparison subjects. Conclusions: These findings suggest greater phospholipid breakdown even in young first-degree relatives of patients with schizophrenia. This suggestion is discussed with respect to the membrane phospholipid hypothesis of schizophrenia.

引用

页码：958 / 960

页数：3

共 15 条

[1] Common pattern of cortical pathology in childhood-onset and adult-onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging [J].