The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease

被引：149

作者：

Fairbairn, Lynsey

Kapetanovic, Ronan

Sester, David P.

Hume, David A. ^{[1
]}

机构：

[1] Univ Edinburgh, Roslin Inst, Roslin BioCtr, Roslin EH25 9PS, Midlothian, Scotland

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2011年 / 89卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

hematopoiesis; inflammation; host-pathogen interactions; TOLL-LIKE RECEPTOR; COLONY-STIMULATING FACTOR; RESPIRATORY-SYNDROME-VIRUS; TUMOR-NECROSIS-FACTOR; SWINE-FEVER VIRUS; PORCINE ALVEOLAR MACROPHAGES; NITRIC-OXIDE SYNTHASE; C-TYPE LECTIN; DENDRITIC CELLS; IN-VITRO;

D O I：

10.1189/jlb.1110607

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The biology of cells of the mononuclear phagocyte system has been studied extensively in the mouse. Studies of the pig as an experimental model have commonly been consigned to specialist animal science journals. In this review, we consider some of the many ways in which the innate immune systems of humans differ from those of mice, the ways that pigs may address the shortcomings of mice as models for the study of macrophage differentiation and activation in vitro, and the biology of sepsis and other pathologies in the living animal. With the completion of the genome sequence and the characterization of many key regulators and markers, the pig has emerged as a tractable model of human innate immunity and disease that should address the limited, predictive value of rodents in preclinical studies. J. Leukoc. Biol. 89: 855-871; 2011.

引用

页码：855 / 871

页数：17

共 245 条

[1] DISTRIBUTION OF ANTI-CD68 (EBM11) IMMUNOREACTIVITY IN FORMALIN-FIXED, PARAFFIN-EMBEDDED BOVINE-TISSUES [J].

ACKERMANN, MR ;

DEBEY, BM ;

STABEL, TJ ;

GOLD, JH ;

MEEHAN, JT .

VETERINARY PATHOLOGY, 1994, 31 (03) :340-348

[2] Systems biology: Its practice and challenges [J].

Aderem, A .

CELL, 2005, 121 (04) :511-513

[3] African swine fever virus multigene family 360 and 530 genes affect host interferon response [J].

Afonso, CL ;

Piccone, ME ;

Zaffuto, KM ;

Neilan, J ;

Kutish, GF ;

Lu, Z ;

Balinsky, CA ;

Gibb, TR ;

Bean, TJ ;

Zsak, L ;

Rock, DL .

JOURNAL OF VIROLOGY, 2004, 78 (04) :1858-1864

[4] Innate immune responses to replication of porcine reproductive and respiratory syndrome virus in isolated swine alveolar macrophages [J].

Ait-Ali, Tahar ;

Wilson, Alison D. ;

Westcott, David G. ;

Clapperton, Mary ;

Waterfall, Martin ;

Mellencamp, Martha A. ;

Drew, Trevor W. ;

Bishop, Stephen C. ;

Archibald, Alan L. .

VIRAL IMMUNOLOGY, 2007, 20 (01) :105-118

[5]

Akira S, 2006, CURR TOP MICROBIOL, V311, P1

[6] Molecular cloning characterization and expression of porcine immunoreceptor SIRPα [J].

Alvarez, Belen ;

Gomez, Nuria ;

Garrido, Juan Jose ;

Yerle, Martine ;

Revilla, Concepcion ;

Chamorro, Sonia ;

Alonso, Fernando ;

Dominguez, Javier ;

Ezquerra, Angel .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2007, 31 (03) :307-318

[7] Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+and CD16-monocyte subsets [J].

Ancuta, Petronela ;

Liu, Kuang-Yu ;

Misra, Vikas ;

Wacleche, Vanessa Sue ;

Gosselin, Annie ;

Zhou, Xiaobo ;

Gabuzda, Dana .

BMC GENOMICS, 2009, 10 :403

[8] Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care [J].

Angus, DC ;

Linde-Zwirble, WT ;

Lidicker, J ;

Clermont, G ;

Carcillo, J ;

Pinsky, MR .

CRITICAL CARE MEDICINE, 2001, 29 (07) :1303-1310

[9] Septic shock [J].

Annane, D ;

Bellissant, E ;

Cavaillon, JM .

LANCET, 2005, 365 (9453) :63-78

[10] THE PIGMAP CONSORTIUM LINKAGE MAP OF THE PIG (SUS SCROFA) [J].

ARCHIBALD, AL ;

HALEY, CS ;

BROWN, JF ;

COUPERWHITE, S ;

MCQUEEN, HA ;

NICHOLSON, D ;

COPPIETERS, W ;

VANDEWEGHE, A ;

STRATIL, A ;

WINTERO, AK ;

FREDHOLM, M ;

LARSEN, NJ ;

NIELSEN, VH ;

MILAN, D ;

WOLOSZYN, N ;

ROBIC, A ;

DALENS, M ;

RIQUET, J ;

GELLIN, J ;

CARITEZ, JC ;

BURGAUD, G ;

OLLIVIER, L ;

BIDANEL, JP ;

VAIMAN, M ;

RENARD, C ;

GELDERMANN, H ;

DAVOLI, R ;

RUYTER, D ;

VERSTEGE, EJM ;

GROENEN, MAM ;

DAVIES, W ;

HOYHEIM, B ;

KEISERUD, A ;

ANDERSSON, L ;

ELLEGREN, H ;

JOHANSSON, M ;

MARKLUND, L ;

MILLER, JR ;

DEAR, DVA ;

SIGNER, E ;

JEFFREYS, AJ ;

MORAN, C ;

LETISSIER, P ;

MULADNO ;

ROTHSCHILD, MF ;

TUGGLE, CK ;

VASKE, D ;

HELM, J ;

LIU, HC ;

RAHMAN, A .

MAMMALIAN GENOME, 1995, 6 (03) :157-175

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