An array of Pt-tip microelectrodes for extracellular monitoring of activity of brain slices

被引：49

作者：

Thiébaud, P

Beuret, C

Koudelka-Hep, M

Bove, M

Martinoia, S

Grattarola, M

Jahnsen, H

Rebaudo, R

Balestrino, M

Zimmer, J

Dupont, Y

机构：

[1] Univ Neuchatel, Inst Microtechnol, CH-2007 Neuchatel, Switzerland

[2] Univ Genoa, Dept Biophys & Elect Engn, I-16145 Genoa, Italy

[3] Univ Copenhagen, Panum Inst, Inst Med Physiol, DK-2200 Copenhagen, Denmark

[4] Univ Genoa, Dipartimento Sci Neurol, I-16132 Genoa, Italy

[5] Inst Med Biol, Dept Anat & Cell Biol, DK-5000 Odense, Denmark

[6] Biolog, F-38640 Claix, France

来源：

BIOSENSORS & BIOELECTRONICS | 1999年 / 14卷 / 01期

关键词：

extracellular recording; impedance; microelectrode arrays; Pt-tip microelectrode;

D O I：

10.1016/S0956-5663(98)00098-0

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A microelectrode array (MEA) consisting of 34 silicon nitride passivated Pt-tip microelectrodes embedded on a perforated silicon substrate (porosity 35%) has been realized. The electrodes are 47 mu m high, of which only the top 15 mu m are exposed Pt-tips having a curvature of 0.5 mu m. The MEA is intended for extracellular recordings of brain slices in vitro. Here we report the fabrication, characterization and initial electrophysiological evaluation of the first generation of Pt-tip MEAs. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：61 / 65

页数：5

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