International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations

被引：237

作者：

Barouch, Dan H. ^{[1
,2
]}

Kik, Sandra V. ^{[3
]}

Weverling, Gerrit J. ^{[3
]}

Dilan, Rebecca ^{[1
]}

King, Sharon L. ^{[1
]}

Maxfield, Lori F. ^{[1
]}

Clark, Sarah ^{[1
]}

Ng'ang'a, David ^{[1
]}

Brandariz, Kara L. ^{[1
]}

Abbink, Peter ^{[1
]}

Sinangil, Faruk ^{[4
]}

de Bruyn, Guy ^{[5
]}

Gray, Glenda E. ^{[5
]}

Roux, Surita ^{[6
]}

Bekker, Linda-Gail ^{[6
]}

Dilraj, Athmanundh ^{[7
]}

Kibuuka, Hannah ^{[8
]}

Robb, Merlin L. ^{[9
]}

Michael, Nelson L. ^{[9
]}

Anzala, Omu ^{[10
]}

Amornkul, Pauli N. ^{[11
]}

Gilmour, Jill ^{[11
,12
]}

Hural, John ^{[13
]}

Buchbinder, Susan P. ^{[14
]}

Seaman, Michael S. ^{[1
]}

Dolin, Raphael ^{[1
]}

Baden, Lindsey R. ^{[15
]}

Carville, Angela ^{[16
]}

Mansfield, Keith G. ^{[16
]}

Pau, Maria G. ^{[3
]}

Goudsmit, Jaap ^{[3
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02215 USA

[2] Ragon Inst MGH MIT & Harvard, Boston, MA USA

[3] Crucell Holland BV, Leiden, Netherlands

[4] Global Solut Infect Dis, San Francisco, CA USA

[5] Univ Witwatersrand, Johannesburg, South Africa

[6] Univ Cape Town, ZA-7925 Cape Town, South Africa

[7] S African MRC, Durban, South Africa

[8] Makerere Univ, Walter Reed Project, Kampala, Uganda

[9] US Mil HIV Res Program, Walter Reed Army Inst Res, Rockville, MD USA

[10] Univ Nairobi, Nairobi, Kenya

[11] Int AIDS Vaccine Initiat, New York, NY USA

[12] Univ London Imperial Coll Sci Technol & Med, London, England

[13] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[14] San Francisco Dept Publ Hlth, San Francisco, CA USA

[15] Brigham & Womens Hosp, Boston, MA 02115 USA

[16] New England Primate Res Ctr, Southborough, MA USA

来源：

VACCINE | 2011年 / 29卷 / 32期

基金：

比尔及梅琳达.盖茨基金会; 美国国家卫生研究院;

关键词：

Adenovirus; Vector; Vaccine; HIV-1; RHESUS-MONKEYS; HIV-1; VACCINE; NEUTRALIZING ANTIBODIES; GENE-TRANSFER; DOUBLE-BLIND; VECTORS; IMMUNITY; IMMUNOGENICITY; TYPE-5; TRIAL;

D O I：

10.1016/j.vaccine.2011.05.025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recombinant adenovirus serotype 5 (rAd5) vaccine vectors for HIV-1 and other pathogens have been shown to be limited by high titers of Ad5 neutralizing antibodies (NAbs) in the developing world. Alternative serotype rAd vectors have therefore been constructed. Here we report Ad5, Ad26, Ad35, and Ad48 NAb titers in 4381 individuals from North America, South America, sub-Saharan Africa, and Southeast Asia. As expected, Ad5 NAb titers were both frequent and high magnitude in sub-Saharan Africa and Southeast Asia. In contrast, Ad35 NAb titers proved infrequent and low in all regions studied, and Ad48 NAbs were rare in all regions except East Africa. Ad26 NAbs were moderately common in adults in sub-Saharan Africa and Southeast Asia, but Ad26 NAb titers proved markedly lower than Ad5 NAb titers in all regions, and these relatively low Ad26 NAb titers did not detectably suppress the immunogenicity of 4 X 10(10) vp of a rAd26-Gag/Pol/Env/Nef vaccine in rhesus monkeys. These data inform the clinical development of alternative serotype rAd vaccine vectors in the developing world. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5203 / 5209

页数：7

共 23 条

[1] Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D [J].

Abbink, Peter ;

Lemckert, Angelique A. C. ;

Ewald, Bonnie A. ;

Lynch, Diana M. ;

Denholtz, Matthew ;

Smits, Shirley ;

Holterman, Lennart ;

Damen, Irma ;

Vogels, Ronald ;

Thorner, Anna R. ;

O'Brien, Kara L. ;

Carville, Angela ;

Mansfield, Keith G. ;

Goudsmit, Jaap ;

Havenga, Menzo J. E. ;

Barouch, Dan H. .

JOURNAL OF VIROLOGY, 2007, 81 (09) :4654-4663

[2] Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity [J].

Barouch, DH ;

Pau, MG ;

Custers, JHHV ;

Koudstaal, W ;

Kostense, S ;

Havenga, MJE ;

Truitt, DM ;

Sumida, SM ;

Kishko, MG ;

Arthur, JC ;

Korioth-Schmitz, B ;

Newberg, MH ;

Gorgone, DA ;

Lifton, MA ;

Panicali, DL ;

Nabel, GJ ;

Letvin, NL ;

Goudsmit, J .

JOURNAL OF IMMUNOLOGY, 2004, 172 (10) :6290-6297

[3] Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial [J].

Buchbinder, Susan P. ;

Mehrotra, Devon V. ;

Duerr, Ann ;

Fitzgerald, Daniel W. ;

Mogg, Robin ;

Li, David ;

Gilbert, Peter B. ;

Lama, Javier R. ;

Marmor, Michael ;

del Rio, Carlos ;

McElrath, M. Juliana ;

Casimiro, Danilo R. ;

Gottesdiener, Keith M. ;

Chodakewitz, Jeffrey A. ;

Corey, Lawrence ;

Robertson, Michael N. .

LANCET, 2008, 372 (9653) :1881-1893

[4] Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene [J].

Casimiro, DR ;

Chen, L ;

Fu, TM ;

Evans, RK ;

Caulfield, MJ ;

Davies, ME ;

Tang, A ;

Chen, MC ;

Huang, LY ;

Harris, V ;

Freed, DC ;

Wilson, KA ;

Dubey, S ;

Zhu, DM ;

Nawrocki, D ;

Mach, H ;

Troutman, R ;

Isopi, L ;

Williams, D ;

Hurni, W ;

Xu, Z ;

Smith, JG ;

Wang, S ;

Liu, X ;

Guan, LM ;

Long, R ;

Trigona, W ;

Heidecker, GJ ;

Perry, HC ;

Persaud, N ;

Toner, TJ ;

Su, Q ;

Liang, XP ;

Youil, R ;

Chastain, M ;

Bell, AJ ;

Volkin, DB ;

Emini, EA ;

Shiver, JW .

JOURNAL OF VIROLOGY, 2003, 77 (11) :6305-6313

[5] Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector [J].

Catanzaro, Andrew T. ;

Koup, Richard A. ;

Roederer, Mario ;

Bailer, Robert T. ;

Enama, Mary E. ;

Moodie, Zoe ;

Gu, Lin ;

Martin, Julie E. ;

Novik, Laura ;

Chakrabarti, Bimal K. ;

Butman, Bryan T. ;

Gall, Jason G. D. ;

King, C. Richter ;

Andrews, Charla A. ;

Sheets, Rebecca ;

Gomez, Phillip L. ;

Mascola, John R. ;

Nabel, Gary J. ;

Graham, Barney S. .

JOURNAL OF INFECTIOUS DISEASES, 2006, 194 (12) :1638-1649

[6] Adenovirus-Based Vaccines: Comparison of Vectors from Three Species of Adenoviridae [J].

Chen, H. ;

Xiang, Z. Q. ;

Li, Y. ;

Kurupati, R. K. ;

Jia, B. ;

Bian, A. ;

Zhou, D. M. ;

Hutnick, N. ;

Yuan, S. ;

Gray, C. ;

Serwanga, J. ;

Auma, B. ;

Kaleebu, P. ;

Zhou, X. ;

Betts, M. R. ;

Ertl, H. C. J. .

JOURNAL OF VIROLOGY, 2010, 84 (20) :10522-10532

[7] Frequent Detection of Human Adenovirus from the Lower Gastrointestinal Tract in Men Who Have Sex with Men [J].

Curlin, Marcel E. ;

Huang, Meei-Li ;

Lu, Xiaoyan ;

Celum, Connie L. ;

Sanchez, Jorge ;

Selke, Stacy ;

Baeten, Jared M. ;

Zuckerman, Richard A. ;

Erdman, Dean D. ;

Corey, Lawrence .

PLOS ONE, 2010, 5 (06)

[8] Replication-defective vector based on a chimpanzee adenovirus [J].

Farina, SF ;

Gao, GP ;

Xiang, ZQ ;

Rux, JJ ;

Burnett, RM ;

Alvira, MR ;

Marsh, J ;

Ertl, HCJ ;

Wilson, JM .

JOURNAL OF VIROLOGY, 2001, 75 (23) :11603-11613

[9] A simian replication-defective vaccine to HIV-1 gag [J].

Fitzgerald, JC ;

Gao, GP ;

Reyes-Sandoval, A ;

Pavlakis, GN ;

Xiang, ZQ ;

Wlazlo, AP ;

Giles-Davis, W ;

Wilson, JM ;

Ertl, HCJ .

JOURNAL OF IMMUNOLOGY, 2003, 170 (03) :1416-1422

[10]

Flynn MN, 2005, J INFECT DIS, V191, P654, DOI 10.1086/428404

← 1 2 3 →