Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers

被引：114

作者：

Davis, ME ^{[1
]}

Pun, SH ^{[1
]}

Bellocq, NC ^{[1
]}

Reineke, TM ^{[1
]}

Popielarski, SR ^{[1
]}

Mishra, S ^{[1
]}

Heidel, JD ^{[1
]}

机构：

[1] CALTECH, Pasadena, CA 91125 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2004年 / 11卷 / 02期

关键词：

cyclodextrin-polymers; nucleic acid delivery; non-viral delivery; self-assembly; supramolecular structures; gene delivery;

D O I：

10.2174/0929867043456179

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-viral (synthetic) nucleic acid delivery systems have the potential to provide for the practical application of nucleic acid-based therapeutics. We have designed and prepared a tunable, non-viral nucleic acid delivery system that self-assembles with nucleic acids and centers around a new class of polymeric materials: namely, linear, water-soluble cyclodextrin-containing polymers. The relationships between polymer structure and gene delivery are illustrated, and the roles of the cyclodextrin moieties for minimizing toxicity and forming inclusion complexes in the self-assembly processes are highlighted. This vehicle is the first example of a polymer-based gene delivery system formed entirely by self-assembly.

引用

页码：179 / 197

页数：19

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