Integration of metabolism and inflammation by lipid-activated nuclear receptors

被引：671

作者：

Bensinger, Steven J. ^{[1
]}

Tontonoz, Peter ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA 90049 USA

来源：

NATURE | 2008年 / 454卷 / 7203期

关键词：

D O I：

10.1038/nature07202

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The nuclear receptors known as PPARs and LXRs are lipid-activated transcription factors that have emerged as key regulators of lipid metabolism and inflammation. PPARs and LXRs are activated by non-esterified fatty acids and cholesterol metabolites, respectively, and both exert positive and negative control over the expression of a range of metabolic and inflammatory genes. The ability of these nuclear receptors to integrate metabolic and inflammatory signalling makes them attractive targets for intervention in human metabolic diseases, such as atherosclerosis and type 2 diabetes, as well as for the modulation of inflammation and immune responses.

引用

页码：470 / 477

页数：8

共 89 条

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