Anti-inflammatory effect of Atorvastatin (80 mg) in unstable angina pectoris and non-Q-wave acute myocardial infarction

被引：45

作者：

Correia, LCL

Spósito, AC

Lima, JC

Magalhaes, LP

Passos, LCS

Rocha, MS

D'Oliveira, A

Esteves, JP

机构：

[1] Univ Fed Bahia, Sch Med, PhD Program, Salvador, BA, Brazil

[2] Univ Sao Paulo, Sch Med, InCor, Inst Heart, Sao Paulo, Brazil

[3] Portuguese Hosp, Div Cardiol, Salvador, BA, Brazil

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 03期

关键词：

D O I：

10.1016/S0002-9149(03)00630-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this randomized trial, C-reactive protein increased during the first 5 days of an acute coronary syndrome in patients treated with placebo, but this phenomenon was not observed in those randomized to atorvastatin 80 mg/day. This suggests that short-term statin therapy inhibits inflammation in patients with non-ST-elevation acute coronary syndromes. (C)2003 by Excerpta Medica, Inc.

引用

页码：298 / 301

页数：4

共 17 条

[1] Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes
Alaei, P
MacNulty, EE
Ryder, NS
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 222 (01) : 133 - 138
[2] Effect of statin therapy on C-reactive protein levels - The Pravastatin Inflammation/CRP Evaluation (PRINCE): A randomized trial and cohort study
Albert, MA
Danielson, E
Rifai, N
Ridker, PM
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (01): : 64 - 70
[3] Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability
Biasucci, LM
Liuzzo, G
Grillo, RL
Caligiuri, G
Rebuzzi, AG
Buffon, A
Summaria, F
Ginnetti, F
Fadda, G
Maseri, A
[J]. CIRCULATION, 1999, 99 (07) : 855 - 860
[4] Effects of atorvastatin 80 mg daily early after onset of unstable angina pectoris or non-Q-wave myocardial infarction
Colivicchi, F
Guido, V
Tubaro, M
Ammirati, F
Montefoschi, N
Varveri, A
Santini, M
[J]. AMERICAN JOURNAL OF CARDIOLOGY, 2002, 90 (08) : 872 - +
[5] Short-term effect of atorvastatin (80 mg) on plasma lipids of patients with unstable angina pectoris or non-q-wave acute myocardial infarction
Correia, LCL
Spósito, AC
Passos, LCS
Lima, JC
Braga, JC
Rocha, MS
Esteves, JP
D'Oliveira, A
[J]. AMERICAN JOURNAL OF CARDIOLOGY, 2002, 90 (02) : 162 - +
[6] Independent prognostic value of elevated C-reactive protein in unstable angina
Ferreirós, ER
Boissonnet, CP
Pizarro, R
Merletti, PFG
Corrado, G
Cagide, A
Bazzino, OO
[J]. CIRCULATION, 1999, 100 (19) : 1958 - 1963
[7] Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina
Liuzzo, G
Buffon, A
Biasucci, LM
Gallimore, JR
Caligiuri, G
Vitelli, A
Altamura, S
Ciliberto, G
Rebuzzi, AG
Crea, F
Pepys, MB
Maseri, A
[J]. CIRCULATION, 1998, 98 (22) : 2370 - 2376
[8] C-reactive protein and other markers of inflammation among patients undergoing HELP LDL apheresis
Moriarty, PM
Gibson, CA
Shih, J
Matias, MS
[J]. ATHEROSCLEROSIS, 2001, 158 (02) : 495 - 498
[9] Statins and the acute-phase response
Munford, RS
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (26) : 2016 - 2018
[10] Antiinflammatory and antiarteriosclerotic actions of HMG-CoA reductase inhibitors in a rat model of chronic inhibition of nitric oxide synthesis
Ni, WH
Egashira, K
Kataoka, C
Kitamoto, S
Koyanagi, M
Inoue, S
Takeshita, A
[J]. CIRCULATION RESEARCH, 2001, 89 (05) : 415 - 421

← 1 2 →