DNA looping in gene regulation: from the assembly of macromolecular complexes to the control of transcriptional noise

被引:113
作者
Vilar, JMG
Saiz, L
机构
[1] Mem Sloan Kettering Canc Ctr, Computat Biol Ctr, New York, NY 10021 USA
[2] Univ Penn, Ctr Mol Modeling, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
关键词
D O I
10.1016/j.gde.2005.02.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The formation of DNA loops by the binding of proteins and protein complexes at distal DNA sites plays a central role in many cellular processes, such as transcription, recombination and replication. Important thermodynamic concepts underlie the assembly of macromolecular complexes on looped DNA. The effects that this process has on the properties of gene regulation extend beyond the traditional view of DNA looping as a mechanism to increase the affinity of regulatory molecules for their cognate sites. Recent developments indicate that DNA looping can also lead to the suppression of cell-to-cell variability, the control of transcriptional noise, and the activation of cooperative interactions on demand.
引用
收藏
页码:136 / 144
页数:9
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