The CD8 memory T cell subsystem:: Integration of homeostatic signaling during migration

被引：25

作者：

Klonowski, KD ^{[1
]}

Lefrançois, L ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Med, Div Immunol, Farmington, CT 06030 USA

来源：

SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 03期

关键词：

T cells; memory; homeostasis; migration; cytokines;

D O I：

10.1016/j.smim.2005.02.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability of memory CD8 T cells to patrol non-lymphoid tissues represents an effective method whereby proficient immunosurveillance is achieved. From the analysis of memory CD8 T cell migration in vivo, it is clear that tissue-specific factors control trafficking and residence time within tissues. We propose that at least three pools of memory CD8 T cells exist based on migratory capabilities as dictated by their location in the body. Moreover, we hypothesize that the process of acquisition of homeostatic signals in specific tissues, such as the cytokines IL-7 and IL-15, regulates the mobility of memory T cells. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：219 / 229

页数：11

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