Eosinophil recruitment to the airway nerves

被引:74
作者
Jacoby, DB
Costello, RM
Fryer, AD
机构
[1] Johns Hopkins Univ, Johns Hopkins Asthma & Allergy Ctr, Div Pulm & Crit Care Med, Baltimore, MD USA
[2] Natl Univ Ireland Univ Coll Dublin, Beaumont Hosp, RCSI, Dept Med, Dublin, Ireland
[3] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA
关键词
muscarinic receptors; asthma; parasympathetic nerves; hyperresponsiveness; bronchoconstriction;
D O I
10.1067/mai.2001.112940
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Increased vagal reflexes contribute to bronchoconstriction in asthma, Antigen challenge of sensitized animals induces vagal hyperresponsiveness. This review will discuss the evidence that eosinophils increase release of acetylcholine from the parasympathetic nerves. After antigen challenge, eosinophils are actively recruited to the airway nerves, possibly through expression of chemotactic substances and adhesion molecules by the nerves. Tachykinins acting on neurokinin 1 receptors activate the eosinophils. Activated eosinophils release eosinophil major basic protein (MBP), which is an endogenous antagonist for Mt muscarinic receptors. The M-2 muscarinic receptors on the parasympathetic nerves in the lungs normally inhibit release of acetylcholine. When Mt receptors are blocked by MBP, acetylcholine release is increased, resulting in hyperresponsiveness. Neutralization of MBP with polyanionic substances restores Mt receptor function and eliminates hyperresponsiveness. Antibodies to MBP prevent Mt receptor dysfunction and hyperresponsiveness, as do antibodies to the adhesion molecule very late antigen 4, which prevent eosinophil migration. A low dose of dexamethasone, which does not affect total eosinophil influx into the lungs and airways, prevents eosinophils from clustering around the nerves and prevents antigen-induced Mt dysfunction and hyperresponsiveness. Furthermore, animal studies show that viral infections, which are important precipitants of asthma attacks, and exposure to air pollutants such as ozone can also activate airway eosinophils, leading to a chain of events similar to that seen after antigen challenge. Finally, a similar clustering of eosinophils around airway nerves, as well as release of MBP onto the nerves, is seen in fatal asthma, suggesting that similar mechanisms may be involved in human airway hyperresponsiveness.
引用
收藏
页码:211 / 218
页数:8
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