Biochemical roles of testosterone and epitestosterone to 5α-reductase as indicators of male-pattern baldness

被引:39
作者
Choi, MH
Yoo, YS
Chung, BC
机构
[1] Korea Inst Sci & Technol, Bioanal & Biotransformat Res Ctr, Seoul 130650, South Korea
[2] Sungkyunkwan Univ, Coll Pharm, Suwon, South Korea
关键词
dihydrotestosterone; GC-MS; hair; steroids;
D O I
10.1046/j.1523-1747.2001.00188.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
In establishing a theory to predict male-pattern baldness, we investigated the correlation of testosterone, epitestosterone, and dihydrotestosterone with 5 alpha -reductase in hair using gas chromatography-mass spectrometry. One hundred milligram hair samples were obtained from a group of balding subjects and their sons, as well as from a corresponding aged-matched, nonbalding group. The ratio of testosterone to epitestosterone was significantly greater (mean 46.41, p < 0.001; mean 35.83, p < 0.001, respectively) in the hair of balding fathers (n = 19, age 28-50 y) and their sons (n = 16, age 8-16 y) than in the hair of the nonbalding control subjects (mean 9.17 and 10.47, respectively). These findings demonstrate that analysis of terminal hair may not only provide a basis for predicting baldness when the subject is still young, but also for preventing and treating male-pattern baldness by controlling the steroid hormone balance.
引用
收藏
页码:57 / 61
页数:5
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