Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy

被引：48

作者：

Chan, A ^{[1
]}

Reichmann, H ^{[1
]}

Kogel, A ^{[1
]}

Beck, A ^{[1
]}

Gold, R ^{[1
]}

机构：

[1] Univ Wurzburg, Neurol Klin, D-97080 Wurzburg, Germany

来源：

JOURNAL OF NEUROLOGY | 1998年 / 245卷 / 10期

关键词：

bicycle ergometry; coenzyme Q(10); lactate; lactate/pyruvate ratio; mitochondrial encephalomyopathies;

D O I：

10.1007/s004150050267

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We used a standardized bicycle ergometry protocol with a stepwise increasing workload (30-100 W) to evaluate various metabolic factors for the diagnosis and metabolic monitoring of mitochondrial encephalomyopathies. All patients (n = 9) showed pathological venous lactate/pyruvate (L/P) ratios, which normalized in three patients after 6 months of coenzyme Q(10) (CoQ) therapy. Thus, the L/P ratio proved to be the clinically most useful parameter in the evaluation and monitoring of mitochondrial diseases, showing higher sensitivity than lactate measurements only. CoQ may exert a favourable effect in some patients with mitochondrial diseases.

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页码：681 / 685

页数：5

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