Infection of lung epithelial cells and induction of pulmonary adenocarcinoma is not the most common outcome of naturally occurring JS']JSRV infection during the commercial lifespan of sheep

被引:56
作者
Caporale, M
Centorame, P
Giovannini, A
Sacchini, F
Di Ventura, M
De las Heras, M
Palmarini, M
机构
[1] Univ Glasgow, Sch Vet, Inst Comparat Med, Glasgow, Lanark, Scotland
[2] Ist Zooprofilattico Sperimentale Abruzzi & Molise, Teramo, Italy
[3] Univ Zaragoza, Fac Vet, Zaragoza 50013, Spain
关键词
ovine pulmonary adenocarcinoma; OPA; jaagsiekte sheep retrovirus; !text type='JS']JS[!/text]RV; !text type='JS']JS[!/text]RV transmission; retroviruses; retrovirus pathogenesis; sheep;
D O I
10.1016/j.virol.2005.05.018
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA). In this study, we followed over a 31-month period the natural transmission of JSRV in adult sheep and in their offspring. We established groups derived from flocks with either a high or low incidence of OPA and monitored virus transmission, clinical disease and macroscopic/microscopic lung lesions at necropsy. Results obtained show that (i) JSRV infection can occur perinatally or in the first few months of life in lambs and in adult sheep; (ii) only a minority of JSRV-infected animals develop clinical disease during their commercial lifespan; and (iii) JSRV is more readily detectable in peripheral blood leucocytes and lymphoid organs than in the lungs. These data support a model of opportunistic JSRV infection and tumorigenic conversion of type II pneumocytes/Clara cells in the lungs, while lymphoreticular cells serve as the principal virus reservoir. (C) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:144 / 153
页数:10
相关论文
共 45 条
[1]   The jaagsiekte sheep retrovirus envelope gene induces transformation of the avian fibroblast cell line DF-1 but does not require a conserved SH2 binding domain [J].
Allen, TE ;
Sherrill, KJ ;
Crispell, SM ;
Perrott, MR ;
Carlson, JO ;
DeMartini, JC .
JOURNAL OF GENERAL VIROLOGY, 2002, 83 :2733-2742
[2]   MULTIPLE SIGNIFICANCE TESTS - THE BONFERRONI METHOD .10. [J].
BLAND, JM ;
ALTMAN, DG .
BRITISH MEDICAL JOURNAL, 1995, 310 (6973) :170-170
[3]  
Brown P. O., 1997, P161
[4]   Analysis of integration sites of Jaagsiekte sheep retrovirus in ovine pulmonary adenocarcinoma [J].
Cousens, C ;
Bishop, JV ;
Philbey, AW ;
Gill, CA ;
Palmarini, M ;
Carlson, JO ;
DeMartini, JC ;
Sharp, JM .
JOURNAL OF VIROLOGY, 2004, 78 (16) :8506-8512
[5]  
DAWSON M, 1990, BRIT VET J, V146, P531, DOI 10.1016/0007-1935(90)90056-9
[6]  
De Las Heras M, 2003, CURR TOP MICROBIOL, V275, P25
[7]  
DELASHERAS M, IN PRESS RES VET SCI
[8]  
DEMARTINI JC, 1987, J NATL CANCER I, V79, P167
[9]   Jaagsiekte sheep retrovirus proviral clone JS']JSRVJS']JS7, derived from the JS']JS7 lung tumor cell line, induces ovine pulmonary carcinoma and is integrated into the surfactant protein a gene [J].
DeMartini, JC ;
Bishop, JV ;
Allen, TE ;
Jassim, FA ;
Sharp, JM ;
De las Heras, M ;
Voelker, DR ;
Carlson, JO .
JOURNAL OF VIROLOGY, 2001, 75 (09) :4239-4246
[10]  
DUNGAL N, 1946, AM J PATHOL, V22, P737