Comparison of the receptor binding properties of contemporary swine isolates and early human pandemic H1N1 isolates (Novel 2009 H1N1)

被引：70

作者：

Bradley, Konrad C. ^{[1
]}

Jones, Cheryl A. ^{[2
]}

Tompkins, S. Mark ^{[2
]}

Tripp, Ralph A. ^{[2
]}

Russell, Rupert J. ^{[3
]}

Gramer, Marie R. ^{[4
]}

Heimburg-Molinaro, Jamie ^{[5
,6
]}

Smith, David F. ^{[5
,6
]}

Cummings, Richard D. ^{[5
,6
]}

Steinhauer, David A. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[2] Univ Georgia, Dept Infect Dis, Athens, GA 30602 USA

[3] Univ St Andrews, Sch Biol, St Andrews KY16 9ST, Fife, Scotland

[4] Univ Minnesota, Minnesota Vet Diagnost Lab, St Paul, MN 55108 USA

[5] Emory Univ, Sch Med, Dept Biochem, O Wayne Rollins Res Ctr, Atlanta, GA 30322 USA

[6] Emory Univ, Sch Med, Glyc Ctr, O Wayne Rollins Res Ctr, Atlanta, GA 30322 USA

来源：

VIROLOGY | 2011年 / 413卷 / 02期

关键词：

Influenza; Hemagglutinin; Receptor binding; Glycan microarray; Swine influenza; INFLUENZA-A VIRUSES; EMBRYONATED CHICKEN EGGS; UNITED-STATES; H3N2; VIRUSES; B VIRUSES; HONG-KONG; HEMAGGLUTININ; SPECIFICITY; NEURAMINIDASE; A(H1N1);

D O I：

10.1016/j.virol.2011.01.027

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have utilized glycan microarray technology to determine the receptor binding properties of early isolates from the recent 2009 H1N1 human pandemic (pdmH1N1), and compared them to North American swine influenza isolates from the same year, as well as past seasonal H1N1 human isolates. We showed that the pdmH1N1 strains, as well as the swine influenza isolates examined, bound almost exclusively to glycans with alpha 2,6-linked sialic acid with little binding detected for alpha 2,3-linked species. This is highlighted by pair-wise comparisons between compounds with identical glycan backbones, differing only in the chemistry of their terminal linkages. The overall similarities in receptor binding profiles displayed by pdmH1N1 strains and swine isolates indicate that little or no adaptation appeared to be necessary in the binding component of HA for transmission from pig to human, and subsequent human to human spread. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：169 / 182

页数：14

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