Metabolic Connections during Apoptotic Cell Engulfment

被引：133

作者：

Han, Claudia Z. ^{[1
,2
]}

Ravichandran, Kodi S. ^{[1
,2
]}

机构：

[1] Univ Virginia, Dept Microbiol Immunol & Canc Biol, Carter Immunol Ctr, Charlottesville, VA 22908 USA

[2] Univ Virginia, Ctr Cell Clearance, Charlottesville, VA 22908 USA

来源：

CELL | 2011年 / 147卷 / 07期

关键词：

DEAD CELLS; CLEARANCE; PHAGOCYTOSIS; DISEASE; GAMMA;

D O I：

10.1016/j.cell.2011.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phagocyte may manage the excess metabolic load. This Minireview discusses phagocyte cellular metabolism, the digestion of the ingested apoptotic cell, and the impact of these processes on engulfment.

引用

收藏

页码：1442 / 1445

页数：4

相关论文

共 20 条

[1]

AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils [J].

Bae, Hong-Beom ;

Zmijewski, Jaroslaw W. ;

Deshane, Jessy S. ;

Tadie, Jean-Marc ;

Chaplin, David D. ;

Takashima, Seiji ;

Abraham, Edward .

FASEB JOURNAL, 2011, 25 (12) :4358-4368

[2]

Regulation of cancer cell metabolism [J].

Cairns, Rob A. ;

Harris, Isaac S. ;

Mak, Tak W. .

NATURE REVIEWS CANCER, 2011, 11 (02) :85-95

[3]

Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo [J].

Elliott, Michael R. ;

Zheng, Shuqiu ;

Park, Daeho ;

Woodson, Robin I. ;

Reardon, Michael A. ;

Juncadella, Ignacio J. ;

Kinchen, Jason M. ;

Zhang, Jun ;

Lysiak, Jeffrey J. ;

Ravichandran, Kodi S. .

NATURE, 2010, 467 (7313) :333-U114

[4]

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes [J].

Florey, Oliver ;

Kim, Sung Eun ;

Sandoval, Cynthia P. ;

Haynes, Cole M. ;

Overholtzer, Michael .

NATURE CELL BIOLOGY, 2011, 13 (11) :1335-U118

[5]

GONZALEZ N, 2009, IMMUNITY, V31, P245, DOI DOI 10.1016/J.IMMUNI.2009.06.018

[6]

Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues [J].

Gregory, Christopher D. ;

Pound, John D. .

JOURNAL OF PATHOLOGY, 2011, 223 (02) :177-194

[7]

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells [J].

Kao, Aimee W. ;

Eisenhut, Robin J. ;

Martens, Lauren Herl ;

Nakamura, Ayumi ;

Huang, Anne ;

Bagley, Josh A. ;

Zhou, Ping ;

de Luis, Alberto ;

Neukomm, Lukas J. ;

Cabello, Juan ;

Farese, Robert V., Jr. ;

Kenyon, Cynthia .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (11) :4441-4446

[8]

Apoptotic cells induce a phosphatidyiserine-dependent homeostatic response from phagocytes [J].

Kiss, Robert S. ;

Elliott, Michael R. ;

Ma, Zhong ;

Marcel, Yves L. ;

Ravichandran, Kodi S. .

CURRENT BIOLOGY, 2006, 16 (22) :2252-2258

[9]

In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells [J].

Lee, Heung Kyu ;

Mattei, Lisa M. ;

Steinberg, Benjamin E. ;

Alberts, Philipp ;

Lee, Yun Hee ;

Chervonsky, Alexander ;

Mizushima, Noboru ;

Grinstein, Sergio ;

Iwasaki, Akiko .

IMMUNITY, 2010, 32 (02) :227-239

[10]

PPARγ modulated inflammatory response of human dendritic cell subsets to engulfed apoptotic neutrophils [J].

Majai, Gyoengyike ;

Gogolak, Peter ;

Ambrus, Csilla ;

Vereb, Gyoergy ;

Hodrea, Judit ;

Fesues, Laszlo ;

Rajnavoelgyi, Eva .

JOURNAL OF LEUKOCYTE BIOLOGY, 2010, 88 (05) :981-991