Amyloid peptides incorporating a core sequence from the amyloid beta peptide and gamma amino acids: relating bioactivity to self-assembly

被引：25

作者：

Castelletto, Valeria ^{[1
]}

Cheng, Ge ^{[1
]}

Hamley, Ian W. ^{[1
]}

机构：

[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 46期

基金：

英国工程与自然科学研究理事会;

关键词：

X-RAY-DIFFRACTION; ALZHEIMERS-DISEASE; PROTEIN AGGREGATION; INHIBITORS; RECOGNITION; TOXICITY; FRAGMENT; FIBRILLOGENESIS; FIBRILLIZATION; BACKBONE;

D O I：

10.1039/c1cc15493a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of heptapeptides comprising the core sequence A beta(16-20), KLVFF, of the amyloid beta peptide coupled with paired N-terminal gamma-amino acids are investigated in terms of cytotoxicity reduction and binding to the full A beta peptide, both pointing to inhibition of fibrillisation for selected compounds. This is related to the self-assembly capacity of the heptapeptides.

引用

收藏

页码：12470 / 12472

页数：3

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