CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease

被引:147
作者
Elbaz, A
Levecque, C
Clavel, J
Vidal, JS
Richard, F
Amouyel, P
Alpérovitch, A
Chartier-Harlin, MC
Tzourio, C
机构
[1] Natl Inst Hlth & Med Res, INSERM, U360, Paris, France
[2] INSERM, U508, Paris, France
[3] INSERM, U170, Paris, France
[4] Hop St Antoine, Serv Neurol, F-75571 Paris, France
关键词
D O I
10.1002/ana.20051
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We performed a case-control study of Parkinson's disease (PD) in a population characterized by a high prevalence of pesticide exposure and studied the joint effect of pesticide exposure and CYP2D6. Although they are based on a small group of subjects with the joint exposure, our findings are consistent with a gene-environment interaction disease model according to which (1) pesticides have a modest effect in subjects who are not CYP2D6 poor metabolizers, (2) pesticides' effect is increased in poor metabolizers (approximately twofold), and (3) poor metabolizers are not at increased PD risk in the absence of pesticide exposure.
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页码:430 / 434
页数:5
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